Bio-Pharmaceutical Sciences: Drug Discovery and Safety
Drug Discovery and Safety is a specialisation of the Master’s programme Bio-Pharmaceutical Sciences of Leiden University. This specialisation offers scientific training on and hands-on experience with a range of state-of-the-art techniques, required for the discovery and characterization of novel drug targets and the synthesis and optimization of new drugs. Research Project 1 will be conducted at the division Drug Discovery & Safety of the LACDR on one of the research themes described below.
To effectively design new drugs, understanding the mechanism by which potential drug targets affect the development and progression of disease at the molecular level is essential. The division unravels these mechanisms, particularly in the area of (breast) cancer metastasis, drug resistance and drug safety. After screening of candidate drug targets using a ‘systems microscopy’ approach, promising targets are evaluated in clinically relevant models and patient material, in close collaboration with clinical centers.
The division is also working on the design, synthesis and evaluation of new compounds that modulate G protein-coupled receptor activity (GPCRs). Essential is that these compounds meet specific requirements that enable them to work effectively as medicinal agents. To this end, a ‘chemical biology’ approach is pursued in which synthetic chemistry, new developments in bio- and cheminformatics, biochemistry/molecular biology and pharmacology are combined. Finally, the interaction with their targets is modelled and evaluated at atomic resolution for a more rational approach of drug design.