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Reactivity in Organic Chemistry (ROC)


Admission requirements

Core course in MSc Chemistry – Chemical Biology, elective course MSc Chemistry, MSc Life Science and Technology.
For students with a BSc in MST, LST or equivalent. Knowledge of organic chemistry at the level of OC-II (BSc in Chemistry, Molecular Science and Technology, Life Science and Technology or a related discipline) is required.


The course provides the theoretical background necessary for in-depth understanding of organic reaction mechanisms. The course will focus on the role of stereo-electronic factors and conformational effects on the reactivity of molecules, identifying relevant HOMO-LUMO interactions and the application of (simplified) thermodynamics and kinetics, transition state theory and equilibria to understand and predict product distribution in organic reactions.

Course objectives

After the course the student has shown

  • Comprehension/application of reaction mechanisms of the most common transformations in organic chemistry;

  • Comprehension/application of orbital interactions to predict and rationalize reactivity;

  • Comprehension/application of stereoelectronic effects to predict and rationalize reactivity;

  • Comprehension/application of conformational equilibrium and their influence on reactivity;

  • Understanding of pericyclic reactions;

  • Prediction of regio- and stereoselectivity of common organic reactions based on reactivty principles;


Schedule information can be found on the website of the programmes.

Mode of instruction

The class will be given through online classes, online tutorials and on campus tutorials.

Assessment method

Written mid-term test (open book, 20% of total grade)
Written exam (open book, 80% of total grade)

Reading list

Clayden, Greeves & Warren, Organic Chemistry, 2nd edition, 2012. ISBN: 978-0-19-927029-3


Register for this course via uSis


Dr. Jeroen Codee, Dr. Dima Filippov


According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.