Core course MSc Chemistry - Chemical Biology, elective course MSc Chemistry, MSc Life Science and Technology.
Suitable for students with a BSc degree in MST, LST, BFW or equivalent. Student should be familiar with fundamental concepts and transformations in organic chemistry at the level of the first year and the second year organic chemistry courses. Students should be able to work mechanisms of the reactions discussed in Chapters 6, 9-11, 15 -17, 19 -26 of the recommended book (Clayden). The students are encouraged to take Synthetic Organic Chemistry (4012SOCH5) and Reactivity of Organic Chemistry (4423RIOCH) before taking this class.
The chemical transformations common in the modern organic chemistry are discussed in depth in the context of total syntheses of complex natural products taken from the contemporary literature. The students are expected to prepare the preassigned articles before the class and to actively participate in the classes that are organized in a form of problem-solving sessions.
After the course the student should be able to:
Understand modern organic transformations;
Understand transition metal catalyzed organic transformations;
Understand and apply modern concepts in organic chemistry;
Prediction of the structure of the product of modern organic reactions;
Design a synthetic route as part of a total synthesis of a complex molecule;
Understand a synthetic organic chemistry publication from recent literature;
Schedule information can be found on the website of the programmes.
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Mode of instruction
The course consists of problem-solving sessions, rather than formal lectures. In weekly sessions, the structure and reactivity of organic compounds are discussed. Students prepare for these sessions by studying selected chapters from Organic Chemistry textbooks, as well as selected relevant papers from the literature.
Written exam (only one textbook of student’s choice is allowed during the exam).
The student obtains a bonus point towards the final grade by working all mechanisms from a recent organic chemistry article of the student’s choice (1 point maximum).
Formative tests during the lectures in the form of web-based quizzes on a suitable online platform
Handouts (via Brightspace) and one organic chemistry book of student’s choice.
Recommended is Organic Chemistry, 2nd edition, Clayden, Greeves and Warren.
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