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Miniaturized Analytical Systems


Admission requirements

Master students of Bio-Pharmaceutical Sciences, Biomedical Sciences, Life Science & Technology, Molecular Science & Technology. Required background knowledge is fundamental knowledge in biology, chemistry (Bachelor’s level) is needed.


In this course, students will be introduced to the main drivers for miniaturization in the drug discovery, and clinical fields, as well as the analytical challenges that arise from these. After this introduction, the course will be divided into two main parts, given by Dr. Wouters, and Dr. Ali respectively. Part I, given by Dr. Wouters, will focus on different steps of a typical miniaturized analytical workflow; sample intake (single cell capillary sampling, microneedles, droplet microfluidics, acoustic sampling, etc.), and sample preparation and sample separation (microfluidics and microfabrication, miniaturized sample preparation, etc.). Part II, given by Dr. Ali, will focus on different analytical techniques that are often used in miniaturized workflows (MS imaging, nanospray MS, microcoil NMR, Raman spectroscopy, etc), data analysis pipelines, as well as the varying applications of miniaturized analytical workflows in drug discovery, medicine, and in portable lab-on-chip solutions.

This course aims to:

  • Understand the drivers for Miniaturized Analytical Systems, including sample- or volume-limited use cases, portability and small footprint, or the unique physical properties of microfluidic systems.

  • Give an introduction in the different design principles of miniaturized analytical workflows.

  • Get familiar with the latest developments in different steps of miniaturized analytical workflows; from sample intake to sample preparation and separation, and data acquisition.

  • Get insight into current applications of miniaturized analytical approaches in the pharmaceutical industry, medicine, lab-on-chip and point-of-care use.

  • Allow the students to design miniaturized analytical workflows to tackle biological, clinical, and pharmaceutical problems.

Note that these are expert lectures series and that hence the content might change every year.

Course objectives

At the end of this course the student is able to:

  • Describe and explain the main drivers for miniaturized analytical systems.

  • Describe and explain the different steps of current miniaturized analytical platforms.

  • Describe and explain the current applications of miniaturized analytical approaches in the pharmaceutical industry, medicine, lab-on-chip, and point-of-care use.

  • Design miniaturized workflows to answer specific experimental needs in biomedical studies.

  • Read scientific literature and can critically reflect on the rational and experimental approach of the study as well as on the results presented and conclusions drawn by the authors.

  • Present a scientific research paper to peers.


You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.

MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).

For more information, watch the video or go the the 'help-page' in MyTimetable. Please note: Joint Degree students Leiden/Delft have to merge their two different timetables into one. This video explains how to do this.

Mode of instruction

Lectures (39.5).
Tutorial (3.5).
Tutoring (7).
Self-tuition (70).

Assessment method

For each individual exam, the grade is expressed either with pass or fail, or by using a decimal integer between 1.0 and 10.0 that should be ≥ 5.5. The final grade is expressed using an integer between 1 and 10 and can be rounded off/up to a half integer, with the exception of the grade 5.5. Final grades between 5.50 and 5.99 will be rounded up to 6.0. The final grade should be 6.0 to successfully complete this course.

Reading list

Will be announced during the course.


From the academic year 2022-2023 on every student has to register for courses with the new enrollment tool MyStudyMap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.

Please note that it is compulsory to both preregister and confirm your participation for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course. Confirming your exam participation is possible until ten days before the exam.

Extensive FAQ's on MyStudymap can be found here.


Coordinator: Dr. Bert Wouters (e-mail:; tel. +31 71 527 6218).
Co-Coordinator: Dr. Ahmed Ali (e-mail:; tel. +31 71 527 2727).


This information is without prejudice. Alterations can be made for next year.