nl en

Physiology, Advanced Concepts


Admission requirements

The course Physiology, Advanced Concepts, is meant for the student who has already followed the course Physiology, Basic Concepts, or has a comparable level of knowledge on cardiovascular, respiratory and renal physiology.


This course focuses on impaired circulation as a result of inflammation, sepsis, endothelial dysfunction, thrombosis, atherosclerosis and vascular remodelling and its consequences for heart, lung and kidney physiology. Subtopics that will be discussed during the course are:

  • endothelial (dys)function

  • (ab)normal hemostasis

  • sepsis

  • vascular responses to Toll-like receptor activation

  • inflammatory & ischemic kidney disease

  • pulmonary arterial hypertension

  • atherosclerosis, coronary artery disease & myocardial infarction

  • heart failure: hemodynamic & electrophysiological effects

Course objectives

After having followed this course, students should have a clear understanding of the major pathophysiological processes involved in blood flow impairment and its consequences for heart, lung and kidney function.


Between semesters, we will transfer from using the scheduling app to using MyTimeTable: all educational activities before 6 February 2023 can be viewed on our LUMC scheduling website or in the scheduling app. View MyTimeTable for your schedule from 6 February onwards.

Mode of instruction

This course consists of lectures, seminars, working groups and self-study assignments.

Assessment method

Written exam.

Reading list

  • Medical Physiology, Boron W & Boulpaep E, eds., 3rd edition, 2016, Elsevier, Philadelphia. PA.

  • Levick's Introduction to Cardiovascular Physiology, Herring H & Paterson DJ, eds., 6th edition, 2018. CRC Press, Boca Raton, FL.

  • Robbins and Cotran Pathologic Basis of Disease. Kumar V, Abbas AK, Aster JC, eds., 9th edition, 2015, Elsevier, Philadelphia. PA.

  • Versteeg HH et al. New fundamentals in hemostasis. Physiol Rev. 2013;93:327-358.

  • Other selected scientific papers and parts of other text books.


Registration must be done via MyStudyMap. Registration in MyStudyMap gives you automatic access to the course in Brightspace. For more information, please visit the Leiden University website for students.