Basic knowledge of principles of neuroscience.
Most important is student’s motivation and interest in the field and in its impact for health and society.
Period: 9 January 2023 - 3 February 2023
The understanding of the neurophysiological basis of animal and human behavior and disease has been rapidly advanced in the last decade by new state-of-the-art experimental methods in neuroscience. Among these are tissue culture of brain slices, nerve-muscle preparation, basics and advanced electrophysiological techniques and imaging methods.
The course is a theoretical and practical introduction into some of these methods, and these methods are used on different organizational levels (genes, cell, brain slice, organotypic slice culture, organism). There will be lectures on basic principles in neuroscience, combined with lectures on new state-of-the-art methods. The important players in brain function and the impact of neurophysiology on health and society will be explored by the students through a journal club (e.g. aging brain), a plenary discussion forum (e.g. sex differences), culminating in a written and oral application for a self-defined PhD-project (form networks and practice your next step).
Program of the course
Lectures will be given on basic principles in neuroscience as well as on special research topics. Students will hear and discuss about neurophysiology (e.g. membrane physiology, synaptic transmission and plasticity, neuronal network functions), techniques (e.g. electrophysiology, brain imaging, cellular imaging, brain states and behavioural recordings) and neurological diseases and therapies (e.g. Huntington’s, Parkison’s, brain computer interface). The students will present an article on a new and upcoming topic in neuroscience in a journal club. They will also participate in a plenary discussion on a broader perspective of neurophysiology.
The practical part consists of a few experimental blocks (student groups rotate). Examples are:
In vitro electrophysiology
Neuromuscular junction recordings
Calcium imaging in brain slices
Recording of field potentials in vivo and in vitro
In this practical part, electrophysiological and imaging experiments will be demonstrated, with an active participation of the students. The analysis and interpretation of data requires coordinated team work.
A field trip to the Haarlem museum for Psychiatry (Museum het Dolhuys).
Each student will finish with a written PhD proposal on a topic that they themselves can select. They will prepare an application for a PhD position at a university of choice and orally present their project.
Evaluates lectures critically and constructively and is able to reflect on the content which has been discussed
Gains insight in several experimental techniques through demos
Defends his/her opinion from a broad perspective
Shows awareness of relevance of theoretical backgrounds of the course content which has been discussed
Applies newly gained insights in presentation and discussion of a paper
Formulates good scientific questions
Writes an application for a PhD position accompanied by a mini-proposal which incorporates acquired knowledge in the field of neurophysiology and shows clinical relevance if applicable
Defends his/her application adequately to a committee
All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.
Mode of instruction
Lectures, practicals, tutorials, journal club, workshops with self-study assignment, recapitulation sessions.
Written application/proposal (25%)
Oral application (10%)
Recap sessions (short presentation and contribution to discussion) (25%)
Journal club presentation (of paper) (20%)
Plenary discussion (10%)
Practicum report and presentation (10%)
Will be distributed during the course.
Registration for FOS courses, H2W, Scientific Conduct, Course on Lab Animal Sciences and CRiP takes place in lottery rounds in the beginning of July. After the lottery rounds: if you want to register for a course you are kindly asked to contact the student administration at firstname.lastname@example.org.