Basic understanding of Immunology, Pathogen Host interactions and Cell Biochemistry. Successful completion of How To Write a Research Proposal is strongly recommended. Students should be available for all days during this 4-weeks course.
Period: October 19th, 2020 - November 13th, 2020
The main theme of this advanced course is to get insight into the newest developments in immunology, notably by getting acquainted with the emerging fields of immunometabolism and chemical immunology. The main goals of the course include a detailed understanding of the complex interactions between metabolically highly active cell types (such as fat cells and microbes) and immune (effector) cells, as well as the understanding of available cutting-edge chemical tools that can be used for studying immunological processes. Furthermore, this course focuses on the metabolic pathways within immune cells and their relation to immune functions. This course will provide detailed insights into the latest developments in fundamental biological research aiming at understanding the complex interactions between metabolic and immune cells as well as into advanced immunological techniques and some aspects of today’s clinical practice. It is expected that further development of these novel fields of research will lead to better insights and new therapies against infectious and immune-mediated diseases.
An introduction into 1) the basic concepts of the bi-directional interactions between immune cells and metabolically highly active cells, the microbiome, as well as their metabolites, 2) the metabolic activities of immune cells, and 3) an introduction on chemical tools that can be used for immunological research, including lectures, interactive tutorials, and literature presentations and discussions by students.
Week 2 and 3:
In-lab trainings. Students will choose between various research projects offered by the departments involved in the course. During these two weeks the students will closely collaborate with PhD students involved in the research chosen by the student. This intensive in-lab training period consists of both theoretical and practical work and is mainly aimed at providing the practical skills necessary to conduct a short research project in the fields of immunometabolism or chemical immunology. This training period will end with a mini-symposium in which all student groups will present their results to tutors and their fellow students.
A self-study assignment will take place during the last week of the course, under supervision of a tutor. The students will integrate the theoretical and practical knowledge acquired in the first weeks of the course into a research plan in which a hypothesis will be formulated and a research plan will be developed to address this hypothesis. A symposium will be held on the last day of the course during which all students will present their research plan. The written version of the research plan has to be handed in no later than the first Monday after the end of the course.
This course will train the students in particular in:
Assimilating and critically assessing knowledge reported in the scientific literature and in opinions from others, formulating and motivating one’s own opinions. In-lab training related to a research project, defining a research question, writing a research plan, analyzing data with tutors, choosing appropriate techniques, integrate different biomedical disciplines in the design of a research question, design methods, and implement these new research tools, formulate research questions for the future.
Commitment, motivation and drive, collaborating with peers, respecting the rules of the group. Ability to multi-task (work at several assignments, different topics during the course). Writing reports and well-defined research plans.
The student will obtain a broader and deeper insight into:
the interactions between immune cells and metabolic cells (e.g. various fat cells and microbiota) and the role played by these interactions in the regulation of whole-body metabolic homeostasis
the metabolic reactions within immune cells involved in the control of their functions
the chemical tools available for immunological research and some of their applications
the current challenges in immunology and immunometabolism
The student needs to be able to:
formulate hypotheses regarding current challenges in immunology and immunometabolism, and also prepare an essay including a (small) experimental design to address such a hypothesis using the (chemical) tools presented during the course.
assess targets for therapy of infectious and immunological diseases using their knowledge of the immune systems and the metabolism of host cells and microbes
All course and group schedules are published on our LUMC scheduling website or on the LUMC scheduling app.
Mode of instruction
Lectures, self-study, work groups, in-lab training, research assignment.
Pro-active behavior is expected from the student.
Written reports/research plan, oral presentations, student performance and involvement.
Alberts B. et al, Molecular Biology of the Cell, 4th ed. 2002 New York: Garland. Chapter 15.
Parham P. The Immune System, recent edition, new York and London, Garland.
Swanson et al. Microbe, 2nd ed. Washingthon DC, ASM Press.
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