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Quantitative Pharmacology



This lecture series comprises the theoretical basis and application of quantitative pharmacology, with specific focus on population pharmacokinetic-pharmacodynamic (PK-PD) modeling.
Characterizing and predicting the onset, intensity, and duration of drug effects in individuals as well as in populations, requires quantification of both drug exposure (PK) and response (PD). This can be done using mathematical equations and statistical principles that reflect both the different processes underlying drug PK and PD and the inter-individual variability in these processes. This lecture series will cover general quantitative pharmacological concepts, mathematical and statistical concepts involved in population PK-PD modeling, as well as methodological aspects regarding data analysis with the population approach.


Dr. E.H.J. Krekels


Students of Bio-Pharmaceutical Sciences.

Admission requirements

Adequate knowledge of Pharmacology and Statistics.
A minimum of 5 students is required.

Mode of Instruction

The course will mainly consist of lectures and group discussions. Active participation in the discussions and self-study skills are required for this course.


Written Exam and active participation.

Time table

The course is usually taught in February / March.


Application via uSis.


When the number of applicants exceeds the capacity of the course, preference is given to students in the specialisation Systems Pharmacology of Bio-Pharmaceutical Sciences.