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Cross-domain chromatin organisation (CDC)


Admission requirements

This course is an elective course for MSc Life Science and Technology and MSc Chemistry students
Suitable for students with a BSc in MST or LST. Other candidates should have a solid background in molecular and cell biology.


In this course current topics relating to chromatin organization and genome activity across the three domains of life (eukaryotes, archaea and bacteria) will be discussed. Following an overview of basic concepts of chromatin organization in different species, the interplay of chromatin structure with cellular processes will be discussed. Novel techniques for studying these aspects will be highlighted, as well as novel approaches to manipulate chromatin organization with applications in research and medicine.

Topics will be discussed based on recent review and research articles, as well as current research within the research institute.

Course objectives

At the end of the course students:

  • Will have an overview of the mechanisms by which chromatin is organized across the domains of life, with emphasis on similarities and differences.

  • Will have insight in the effects of chromatin organization on processes occurring in a chromatin context.

  • Will have an overview of novel techniques and approaches to study and manipulate chromatin

  • Will be able to discuss verbally as well as in writing specific topics related to the content of this course

  • Will be able to critically evaluate manuscripts of others and implement feedback in their own manuscripts

  • Can digest and present a summary of a scientific article from the literature


Schedule information can be found on the website of the programmes.

You will find the timetables for all courses and degree programmes of Leiden University in the tool MyTimetable (login). Any teaching activities that you have sucessfully registered for in MyStudyMap will automatically be displayed in MyTimeTable. Any timetables that you add manually, will be saved and automatically displayed the next time you sign in.

MyTimetable allows you to integrate your timetable with your calendar apps such as Outlook, Google Calendar, Apple Calendar and other calendar apps on your smartphone. Any timetable changes will be automatically synced with your calendar. If you wish, you can also receive an email notification of the change. You can turn notifications on in ‘Settings’ (after login).

For more information, watch the video or go the the 'help-page' in MyTimetable. Please note: Joint Degree students Leiden/Delft have to merge their two different timetables into one. This video explains how to do this.

Mode of instruction

Lectures, discussions, lab visits.

Assessment method

  • Essay (50%)

  • Presentation (20%)

  • Review of essays (30%)

Participation in the reviewing of essays and attendance at presentations is obligatory.
Changes to the assessment method will be announced via Brightspace a minimum of 10 working days before the originally scheduled deadline.

Reading list

Articles on the topic of each lecture will be provided via Brightspace. Relevant literature for writing of the essay will need to be identified by the students.


From the academic year 2022-2023 on every student has to register for courses with the new enrollment tool MyStudyMap. There are two registration periods per year: registration for the fall semester opens in July and registration for the spring semester opens in December. Please see this page for more information.

Please note that it is compulsory to both preregister and confirm your participation for every exam and retake. Not being registered for a course means that you are not allowed to participate in the final exam of the course. Confirming your exam participation is possible until ten days before the exam.

Extensive FAQ's on MyStudymap can be found here.


Remus Dame


Assignment deadlines are communicated via Brightspace.

According to OER article 4.8, students are entitled to view their marked examination for a period of 30 days following the publication of the results of a written examination. Students should contact the lecturer to make an appointment for such an inspection session.